346. WE-Heraeus-Seminar
Cardiovascular physics is a new interdisciplinary research area, which interconnects cardiology, nonlinear dynamics and statistics, i.e. subareas from medicine, physics and mathematics. The research goal is to improve clinical diagnostics via model-based nonlinear-dynamic data analysis from non-invasively measured biosignals. Using modern nonlinear methods in multivariate analysis of synchronously measured electrocardiograms, blood pressure, breathing or oxygen saturation signals, etc... the understanding of the cardiovascular regulation should be improved to answer clinically relevant questions.
Pathological changes of the cardiovascular system belong to the category of dynamic diseases, i.e. the associated physiological processes are characterised by sudden (qualitative) changes and rich dynamics. Thus, the focus of nonlinear dynamics aims exactly at describing and analysing these medical phenomena. First applications of nonlinear dynamics in medical diagnostics were successful during the last 10 years
(Focus Issue CHAOS 1995;  Kantz 1998). So far, however, either only data were analysed (Poon 1997;  Ivanov 1996,1999; Schmidt 1999, Yang 2003, Wessel 2004) or models developed (Focus Issue CHAOS 2002;  Wikswo 1995;  Grey 1998;  Witkowski 1998, Special Issue:  Int J Bifurcat Chaos 2003). The time has come now to begin the qualitatively new step: the connection between data analysis and modelling. The emphasis is on the space-time modelling for the characterisation of autonomous vegetative regularization by means of arrhythmia -, variability -, interaction- and synchronisation analyses based on procedures of nonlinear dynamics.
Applications of the research results are various: monitoring -, diagnosis -, course and mortality prognoses as well as the early detection of heart diseases. For clinical applications there is an extraordinary demand of new computer-controlled diagnostic methods to get an exact and differentiated impression of the possibly damaged heart. Therefore, the goal of this seminar is to bring together theoretical physicists and physicians, to discuss interdisciplinary the possibilities of cardiovascular physics and to initiate new promising scientific projects.