physics is a new interdisciplinary research area, which interconnects cardiology,
nonlinear dynamics and statistics, i.e. subareas from medicine, physics and
mathematics. The research goal is to improve clinical diagnostics via model-based
nonlinear-dynamic data analysis from non-invasively measured biosignals.
Using modern nonlinear methods in multivariate analysis of synchronously
measured electrocardiograms, blood pressure, breathing or oxygen saturation
signals, etc... the understanding of the cardiovascular regulation should
be improved to answer clinically relevant questions.
Pathological changes of the cardiovascular system belong to the category
of dynamic diseases, i.e. the associated physiological processes are characterised
by sudden (qualitative) changes and rich dynamics. Thus, the focus of nonlinear
dynamics aims exactly at describing and analysing these medical phenomena.
First applications of nonlinear dynamics in medical diagnostics were successful
during the last 10 years (Focus Issue CHAOS 1995; Kantz
1998). So far, however, either only data were analysed (Poon 1997; Ivanov 1996,1999; Schmidt
1999, Yang 2003, Wessel 2004) or models developed (Focus Issue CHAOS 2002; Wikswo
1995; Grey 1998; Witkowski 1998, Special Issue: Int J
Bifurcat Chaos 2003). The time has come now to begin the qualitatively new
step: the connection between data analysis and modelling. The emphasis is
on the space-time modelling for the characterisation of autonomous vegetative
regularization by means of arrhythmia -, variability -, interaction- and
synchronisation analyses based on procedures of nonlinear dynamics.
Applications of the research results are various: monitoring -, diagnosis
-, course and mortality prognoses as well as the early detection of heart
diseases. For clinical applications there is an extraordinary demand of new
computer-controlled diagnostic methods to get an exact and differentiated
impression of the possibly damaged heart. Therefore, the goal of this seminar
is to bring together theoretical physicists and physicians, to discuss interdisciplinary
the possibilities of cardiovascular physics and to initiate new promising
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